• MRS. ANJANA GEORGE
• MRS. ATHIRA ANILKUMAR
• MS. MARIA JOSEPH
• MS. MEENAKSHY RAJEEV

Neurodegenerative disorders (NDs) embrace a collective group of conditions portrayed by the gradual loss of neurons, leading to dementia, motor dysfunction, and other neurological defects. Major NDs include Alzheimer's Disease (AD), Parkinson’s Disease (PD), Huntington’s Disease (HD), and Amyotrophic Lateral Sclerosis (ALS), each carrying distinct clinical manifestations and pathogenic mechanisms such as protein aggregation, oxidative stress, and neuroinflammation. Globally, neurological diseases affect billions, with AD and PD reported as ubiquitous among other NDs, seemingly increasing in number with the progression of age. Though conventional drug therapies offer symptomatic relief, their effectiveness is hampered by limited brain drug delivery and the blood-CSF barrier, followed by different adverse reactions. Advanced therapeutic interventions, including monoclonal antibodies, precision medicine, advanced drug delivery systems, and gene and stem cell therapies, promise to slow disease progression. However, challenges, including late diagnosis and high out-of-pocket expenses, increase the risk of incidence. Emerging interventions like deep brain stimulation and novel site-specific drug delivery techniques show promise for PD and AD, as well as supportive care for less common NDs such as HD and FTD. Despite these advances, early diagnosis and effective disease-modifying treatments remain critical unmet needs in managing neurodegeneration at a global scale.

Alzheimer’s Disease, Parkinson’s Disease, Precision medicine, Targeted therapy, Deep brain stimulation

"NEURODEGENERATIVE DISORDERS: A COMPREHENSIVE INSIGHT INTO CURRENT AND EMERGING THERAPEUTIC APPROACHES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.c210-c224, December-2025, Available :http://www.jetir.org/papers/JETIR2512225.pdf

"NEURODEGENERATIVE DISORDERS: A COMPREHENSIVE INSIGHT INTO CURRENT AND EMERGING THERAPEUTIC APPROACHES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppc210-c224, December-2025, Available at : http://www.jetir.org/papers/JETIR2512225.pdf