• Kavana Shree H
• Lakshmi Radhika G
• Hemanth S N
• Venkanagouda Shridharagouda Agasimundin

One of the human body’s most extensive and easily accessible organs, the skin has many advantages over oral drug delivery methods. These benefits includes better patient compliance, prevention of gastrointestinal issues and first pass metabolism, and less variation in plasma drug levels. Transdermal drug delivery systems (TDDS) are self-contained, discrete dose forms that distribute medications to the systemic circulation at a regulated rate when applied to intact skin. Bangham et al. first described niosomes in 1965. Niosomes, sometimes called non-ionic surfactant vesicles (NSVs), are tiny particles (nanoparticles) in which the core contents are encased in a vesicle made of non-ionic surface-active agents. These Niosomes are created as non-invasive drug carrier system that can enter the skin, fuse with cell membrane lipids, and release the drug. The Thin-Film Hydration Method (Hand-Shaking Method), Reverse-Phase Evaporation Method (REV), Ether Injection Method, Ethanol Injection Method, and Sonication Method can all be used to create niosomes. Entrapment efficiency, particle size, zeta potential, release percentage, ex-vivo permeability parameters, and stability are among the evaluation criteria for niosomes. Niosomes have been successfully studied for the delivery of several medicines.

Drug delivery, Niosomes, Lipid carriers, Skin permeation, Transdermal.

"Niosomes in Transdermal and Topical Drug Delivery: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.c442-c446, December-2025, Available :http://www.jetir.org/papers/JETIR2512249.pdf

"Niosomes in Transdermal and Topical Drug Delivery: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppc442-c446, December-2025, Available at : http://www.jetir.org/papers/JETIR2512249.pdf