• Yogesh Bacche
• Ashvini Nagare

ABSTRACT: A simple, precise, and accurate UV spectrophotometric method was developed and validated for the stability testing of Mebeverine Hydrochloride (HCl) in pharmaceutical formulations. The method involved the selection of an appropriate wavelength at 220 nm, where Mebeverine HCl exhibited maximum absorbance in a distilled water. The method was validated for parameters such as linearity, accuracy, precision. Linearity was observed in the concentration range of 2–20 µg/mL, with a correlation coefficient (R²) greater than 0.999. The method demonstrated good intra-day and inter-day precision with %RSD values less than 2%. Recovery studies confirmed the accuracy of the method with recoveries ranging from 98% to 102%. Forced degradation studies under various stress conditions (acidic, alkali, oxidative and thermal) confirmed the stability-indicating nature of the method. The proposed UV spectrophotometric method offers a rapid, cost-effective, and reliable analytical tool for the routine quality control and stability assessment of Mebeverine HCl in bulk and pharmaceutical dosage forms.

KEYWORDS: UV visible Spectrophotometer, Mebeverine hydrochloride, Forced degradation

"REVIEW ON THE METHOD DEVELOPMENT OF MEBEVERINE HCL BY SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 12, page no.d155-d161, December-2025, Available :http://www.jetir.org/papers/JETIR2512319.pdf

"REVIEW ON THE METHOD DEVELOPMENT OF MEBEVERINE HCL BY SPECTROSCOPY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 12, page no. ppd155-d161, December-2025, Available at : http://www.jetir.org/papers/JETIR2512319.pdf