• Kotakonda Sreekanth
• Rajasekharan.S

Abstract In present investigation an attempt has been made to formulation and evaluation of immediate release dosage form of entecavir drug. Optimization studies were done for the selection of glidant, lubricant and coating materials. Evaluation of granules was done on the basis of preformulation studies. Pre compression and post compression parameters were evaluated for optimization. The prepared tablets were evaluated for physicochemical properties. The in- vitro release studies were performed as per USP and compared with marketed product. The release of Entecavir were analysed by high performance liquid chromatography (HPLC). Comparative dissolution studies and assays between optimized formulation and reference product showed better release and equivalent drug content. Stabilities studies were performed in both blister as well as cold form blister packings. Stabilities studies revealed the suitability of blister package in comparison to the cold form blister packing. The drug used in this formulation is used for the treatment of Hepatitis-B. Lactose monohydrate is used as diluent in tablet formulation which is safe to diabetic patients.

Entecavir, Hepatitis-B, Immediate Release, Blister packing, Lactose monohydrate.

"FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF ENTECAVIR FOR HEPATITIS-B", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 1, page no.a24-a32, January-2026, Available :http://www.jetir.org/papers/JETIR2601004.pdf

"FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF ENTECAVIR FOR HEPATITIS-B", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 1, page no. ppa24-a32, January-2026, Available at : http://www.jetir.org/papers/JETIR2601004.pdf