• Sachin Mangattu
• Dr. Varsha R. Solanki

Background: Gara Visha, described in classical Ayurvedic literature as Kritrima refers to artificially prepared toxins which results in cumulative toxicity. Progressive impairment of Agni leads to Dhatu dushti and systemic involvement, with Yakrut being the primary organ affected due to its central role in metabolism and detoxification, closely paralleling modern concepts of chronic toxin and drug-induced hepatotoxicity. Aim and Objectives: The present review aims to conceptualize the therapeutic efficacy of Murvadi Agada in the management of Gara Visha-janya Yakrut Roga. Materials and Methods: Classical Ayurvedic texts including Bruhatrayee and Laghutrayee, along with contemporary indexed and non-indexed peer-reviewed journals, were critically reviewed to analyse the pharmacodynamic and therapeutic relevance of Murvadi Agada. Results and Discussion: Murvadi Agada, a classical polyherbal formulation described in Ashtanga Hridaya and Ashtanga Sangraha, consists of ten herbal ingredients predominantly possessing Tikta, Kashaya and Katu Rasa, Laghu and Ruksha Guna, Ushna Veerya, and Katu Vipaka, making it effective in pacifying aggravated Kapha and Vata Doshas. Its Deepana, Pachana, Vishaghna, and Rasayana properties help restore Agni, enhance detoxification, and support hepatic function, while appropriate Anupanas such as Ushnambu, Takra, Mastu, and Amla Rasa Dravyas further enhance therapeutic efficacy. Conclusion: In the context of modern lifestyle-related chronic exposure to food adulterants, preservatives, incompatible diets, and long-term medication use comparable to Gara Visha, Murvadi Agada offers a rational Ayurvedic approach for the management of Gara Visha-janya liver and metabolic disorders.

Murvadi Agada, Gara Visha, Kritrima Visha, Yakrut Roga, Drug-induced hepatotoxicity

"Role of Murvadi Agada in the Management of Gara Visha - janya Yakrut Roga : A conceptual review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 1, page no.a628-a635, January-2026, Available :http://www.jetir.org/papers/JETIR2601075.pdf

"Role of Murvadi Agada in the Management of Gara Visha - janya Yakrut Roga : A conceptual review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 1, page no. ppa628-a635, January-2026, Available at : http://www.jetir.org/papers/JETIR2601075.pdf