• Jalkote Rutuja Satish
• Shaikh K.U.
• Bhalerao Sarika C.
• Mane Ankita S.
• Dake Akshay S. , Pathan Ajhar k.

Tinospora cordifolia, commonly referred to as Guduchi, is a widely recognized medicinal plant in the Ayurvedic system of medicine due to its extensive therapeutic applications. The plant is rich in diverse bioactive constituents such as alkaloids, diterpenoid lactones, glycosides, phenolic compounds, and polysaccharides, which are responsible for its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. Several experimental investigations have confirmed that extracts of Tinospora cordifolia exhibit effective antibacterial and antifungal activity against common pathogenic microorganisms including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, and Aspergillus Niger. In recent pharmaceutical research, topical herbal gels containing Tinospora cordifolia extract have gained considerable attention due to their favorable physicochemical characteristics, good skin compatibility, and enhanced antimicrobial performance. Gel bases such as Carbopol and novel vesicular carriers like transethosomes have been reported to improve skin penetration and sustain the release of active constituents. The present review aims to compile and critically analyze available scientific literature on the pharmacognostic features, phytochemical composition, antimicrobial potential, and formulation approaches of Tinospora cordifolia, highlighting its suitability for the development of an effective herbal antimicrobial gel for topical application.

Tinospora cordifolia; Guduchi; Herbal antimicrobial gel; Phytochemicals; Antibacterial activity; Antifungal activity; Carbopol gel; Topical formulation; Wound healing; Natural antimicrobials.

"A Review on Antimicrobial Herbal Gels Developed Using Tinospora cordifolia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 1, page no.b284-b293, January-2026, Available :http://www.jetir.org/papers/JETIR2601145.pdf

"A Review on Antimicrobial Herbal Gels Developed Using Tinospora cordifolia", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 1, page no. ppb284-b293, January-2026, Available at : http://www.jetir.org/papers/JETIR2601145.pdf