Abstract
Blockchain technology has gained increasing attention as a disruptive digital innovation capable of transforming healthcare systems by enhancing data security, transparency, interoperability, and patient-centric information management. Despite its conceptual and technical promise, blockchain adoption in healthcare remains limited and uneven across regions and stakeholder groups. This paper presents a comprehensive literature review to identify and synthesize the key determinants influencing blockchain technology acceptance in healthcare. Drawing upon more than three decades of technology adoption research and recent blockchain-focused studies, this review integrates findings from empirical research, systematic literature reviews, conceptual frameworks, and doctoral theses. Determinants are categorized into technological, individual, organizational, regulatory, and environmental dimensions, grounded in established theoretical models such as the Technology Acceptance Model (TAM), Unified Theory of Acceptance and Use of Technology (UTAUT/UTAUT2), Diffusion of Innovation (DOI), Trust Theory, and Institutional Theory. The review reveals that perceived usefulness, trust, privacy and security, interoperability, organizational readiness, regulatory support, cost considerations, and stakeholder collaboration are the most frequently cited determinants shaping acceptance behavior among healthcare professionals, patients, administrators, and policymakers. By consolidating fragmented insights across disciplines, this study proposes an integrative determinant framework to guide future empirical research and inform policy and implementation strategies for blockchain-enabled healthcare systems.