• KEERTHI MOHANDAS

A Nanoemul gel is a topical gel that contains a nanoemulsion dispersed within a gel matrix. The nanoemulsion is typically prepared using high-shear mixing techniques and contains droplets of an oil phase dispersed in an aqueous phase, stabilised by surfactants or stabilisers. The resulting Nanoemul gel has several advantages over traditional emulsion-based gels, including improved stability, enhanced drug penetration, and increased bioavailability. Nanoemulsions have been studied for their potential applications in dermatology and drug delivery, yielding promising results in reducing acne lesions, improving skin appearance, and enhancing drug delivery while reducing inflammation. Further research is needed to optimise the formulation and assess the safety and effectiveness of Nanoemulsions for different applications. Nanoemulgel consist of two different systems in which a drug-containing nanoemulsion is incorporated into a gel base. The fusion of these two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated, and the skin permeability of the incorporated drugs can be enhanced several-fold due to the finely distributed oil droplets in the gel phase. Simultaneously, it can be targeted more specifically to the site of action and can avoid first-pass metabolism and relieve the user from gastric/systemic incompatibilities. The nanoemulgel drug delivery system is a formulation-related intervention to improve drug absorption and therapeutic profile of lipophilic drugs. An increasing trend in nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their non-greasy, convenient spreadability, easy applicability and good therapeutic and safety profile. Despite having a few limitations, nanoemulgel formulation can be considered as a potential and promising candidate for the topical delivery of lipophilic drugs in the future.

Nanoemulgel; Topical Formulation; Drug Delivery through skin

"AN OVERVIEW OF NANOEMULGEL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 1, page no.c181-c189, January-2026, Available :http://www.jetir.org/papers/JETIR2601220.pdf

"AN OVERVIEW OF NANOEMULGEL ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 1, page no. ppc181-c189, January-2026, Available at : http://www.jetir.org/papers/JETIR2601220.pdf