Abstract
Vriddhadaru (Argyreia nervosa (Burm.f.) Bojer.), a perennial woody climber belonging to the family Convolvulaceae, is a medicinal plant extensively used in the Ayurvedic system of medicine. Classical Ayurvedic texts describe the plant as Rasayana, Balya, Medhya and Vrishya and recommend its use in neurological disorders (Vatavyadhi), inflammatory conditions (Shotha), metabolic disorders (Prameha), respiratory ailments, wounds, sexual debility and general weakness. In recent years, A. nervosa (Burm.f.) Bojer.) has gained considerable scientific attention due to its wide spectrum of pharmacological activities. Experimental and preclinical studies have reported aphrodisiac, hepatoprotective, central nervous system activity, hypoglycemic and antihyperglycemic, immunomodulatory, anti-inflammatory, anti-convulsant, analgesic, nootropic, antimicrobial, antiviral and nematocidal, gastroprotective activity from various parts of the plant. Phytochemical investigations have revealed the presence of bioactive constituents such as triterpenoids, flavonoids, steroids, lipids, phenolic compounds, aryl esters, coumarins and ergoline alkaloids which may collectively contribute to its therapeutic potential. The present review compiles and critically evaluates available literature on the botanical characteristics, traditional uses, phytochemical profile and pharmacological activities of Argyreia nervosa (Burm.f.) Bojer., thereby providing a scientific basis for its traditional applications and supporting further pharmacological and clinical investigations.