• Dr. Yashashree J. Thakre
• Dr. Trupti A Sarode

The Ayurvedic concept of Ama denotes a fundamental pathological condition characterized by the accumulation of toxic, undigested, or improperly metabolized substances within the body. Classical Ayurvedic texts describe Ama as the Mulakarana (root cause) of disease, arising from impairment of Agni—the digestive and metabolic fire responsible for physiological transformation. In a parallel framework, modern medicine recognizes free radicals, particularly reactive oxygen and nitrogen species, as major contributors to oxidative stress, resulting in cellular injury and the progression of chronic degenerative disorders. This review undertakes a critical comparative analysis of the ancient concept of Ama and the contemporary Free Radical Theory of aging and disease. Evaluation of their physiological characteristics reveals notable similarities: both Ama and free radicals originate endogenously from inefficient metabolic processes, exhibit unstable and reactive properties, and possess the ability to obstruct biological channels (Srotas) and compromise systemic homeostasis. Furthermore, the paper examines the congruence between Ayurvedic therapeutic modalities—Deepana–Pachana (enhancement of digestive and metabolic activity) and Shodhana (biopurificatory procedures)—and modern interventions involving antioxidants and free radical scavengers. This integrative analysis suggests that Ama may be interpreted as a macroscopic clinical manifestation of microscopic oxidative stress. By bridging Ayurvedic and biomedical paradigms, the study offers a comprehensive understanding of systemic inflammation and metabolic disorders, thereby reinforcing the relevance of Ayurvedic principles within contemporary molecular and integrative medicine.

Ama, Bio Markers, Inflammation, Toxins.

"Correlation of Ama Lakshana with Inflammatory Biomarkers – A Rog Nidan Perspectives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 2, page no.a9-a14, February-2026, Available :http://www.jetir.org/papers/JETIR2602002.pdf

"Correlation of Ama Lakshana with Inflammatory Biomarkers – A Rog Nidan Perspectives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 2, page no. ppa9-a14, February-2026, Available at : http://www.jetir.org/papers/JETIR2602002.pdf