• Dr. Muhith Abdul
• Dr. Baishya Anup

Background: Vrana (ulcer/wound) is a complex pathological condition described in Ayurveda as a discontinuity of body tissues, often becoming chronic when associated with systemic and local derangements. Among the various pathogenic factors implicated in the chronicity of Dushta Vrana, Kleda—the pathological expression of excess bodily moisture—plays a pivotal yet underexplored role. Vikrita Kleda, arising from Kapha aggravation, Agnimandya, and Ama formation, contributes to features such as excessive discharge, delayed healing, foul odor, and inflammation. Correlating this classical concept with contemporary inflammatory markers may enhance etiopathological understanding and clinical assessment. Aim and Objectives: The study aimed to establish Vranagata Vikrita Kleda as a distinct etiopathological entity in Vrana and to explore its probable correlation with selected laboratory parameters. Materials and Methods: A clinical observational study was conducted on 100 subjects, comprising 20 patients each of Prameha, Sthaulya, Sotha, Kustha, and Vrana. Patients aged 18–70 years were assessed using a specially designed clinical proforma based on classical Ayurvedic descriptions of Kleda. Subjective and objective features of Vikrita Kleda were evaluated, and laboratory investigations including Total Leukocyte Count (TLC), Erythrocyte Sedimentation Rate (ESR), and C-reactive Protein (CRP) were performed. Vikrita Kleda was considered present when four or more predefined features were observed. Results: Vrana exhibited the highest expression of Vranagata Vikrita Kleda, with Srava and Kandu present in 90% of cases, followed by Klinnata and Vedana in 85%, Chirakari in 65%, and Gandha in 60% of patients. Elevated TLC was observed in 35% of Vrana cases. Inflammatory markers were significantly raised, with ESR elevated in 75% and CRP in 45% of Vrana patients. Additionally, Prameha-associated features were noted in 50% of Vrana cases, indicating a strong metabolic influence on Kleda aggravation and wound chronicity. Conclusion: The study establishes Vranagata Vikrita Kleda as a prominent and clinically relevant etiopathological factor in Vrana.

Vrana, Vikrita Kleda, Dushta Vrana, Prameha, Kapha, Ama, TLC, ESR, CRP

"ETIOPATHOLOGICAL STUDY OF VRANAGATA VIKRITA KLEDA WITH SPECIAL REFERENCE TO LABORATORY PARAMETERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 2, page no.b86-b92, February-2026, Available :http://www.jetir.org/papers/JETIR2602112.pdf

"ETIOPATHOLOGICAL STUDY OF VRANAGATA VIKRITA KLEDA WITH SPECIAL REFERENCE TO LABORATORY PARAMETERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 2, page no. ppb86-b92, February-2026, Available at : http://www.jetir.org/papers/JETIR2602112.pdf