• Pooja Sharma
• Rahul Mathur
• Dr. Jagdish Chandra Rathi

Preformulation studies of Tocopherol confirmed its organoleptic properties as amber to light yellow, odorless, tasteless, and clear viscous oil. Tocopherol was insoluble in water, 0.1N HCl, and phosphate buffer (pH 7.4), but dispersible in these media, while freely soluble in ethanol and methanol, and soluble in acetone. The reported melting point was 3 °C, and λmax was determined at 283 nm in hydro-alcoholic solvent. A standard calibration curve was established within the concentration range of 10–50 µg/ml, yielding a linearity equation y=0.019x−0.010 with R2=0.996. FT-IR analysis confirmed compatibility with excipients and stability of the drug. Five formulations of microencapsulated Tocopherol were prepared using the o/w emulsion solvent evaporation method with varying sodium alginate concentrations, fixed chitosan:Span-40 (2:1) ratio, and 100 mg Tocopherol. Microcapsules were formed using a 26 G needle and 10 ml syringe. Evaluation revealed yields between 85.36–96.35%, mean particle sizes of 283.61 ± 1.05 to 399.52 ± 1.81 µm, encapsulation efficiencies of 88.61 ± 1.26 to 98.83 ± 0.57%, and swelling indices of 3.28–4.47. Among these, formulation M-3 demonstrated superior performance with yield (96.35%), particle size (368.62 µm), encapsulation efficiency (98.83 ± 0.57%), swelling index (4.47), and drug release (94.53%). SEM analysis confirmed smooth surface morphology and regular shape. Kinetic modeling of in-vitro release data indicated that formulation M-3 followed the Higuchi model with R2=0.967. The optimized batch was successfully filled into hard gelatin capsules. Accelerated stability studies conducted for 30 days at 4 °C, 25 °C, and 40 °C revealed no significant variation in drug release, confirming the physical and chemical stability of the optimized microencapsulated Tocopherol formulation

Tocopherol, Vitamin-E, Microcapsules, Encapsulation, controlled release, Neutraceutical

"ENCAPSULATION AND CONTROLLED RELEASE STRATEGY IN NUTRACEUTICAL DELIVERY SYSTEM FOR IMPROVED HEALTH BENEFITS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 2, page no.c418-c424, February-2026, Available :http://www.jetir.org/papers/JETIR2602263.pdf

"ENCAPSULATION AND CONTROLLED RELEASE STRATEGY IN NUTRACEUTICAL DELIVERY SYSTEM FOR IMPROVED HEALTH BENEFITS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 2, page no. ppc418-c424, February-2026, Available at : http://www.jetir.org/papers/JETIR2602263.pdf