• Himanshu Sharma
• Dr Nasiruddin Ahmad Farooqui

Through a simple synthetic process, a number of new substituted imine derivatives (SC1–SC5) were effectively produced employing different substituted aldehydes. Recrystallisation was used to purify the compounds, which were produced in moderate to excellent yields (62–79%). Melting point analysis, thin-layer chromatography (TLC), infrared spectroscopy (IR), proton nuclear magnetic resonance (¹H NMR), and liquid chromatography-mass spectrometry (LC-MS) were used to validate the structure and evaluate purity. The effective conversion of carbonyl groups to imine functionality was demonstrated by IR spectra, and the predicted proton environments were confirmed by ¹H NMR data. The molecular weights and excellent purity of the produced compounds were validated by LC-MS analysis. Moderate inhibitory efficacy against common bacterial strains was found in preliminary antibacterial investigation, with certain compounds showing encouraging results. These results demonstrate the imine derivatives' effective synthesis and characterisation and point to the possibility of more biological research into them.

Heterocyclic compounds Schiff bases Imine derivatives (SC1–SC5) Antibacterial activity Substituted aldehydes Synthesis and characterization Thin Layer Chromatography (TLC) Infrared Spectroscopy (IR) Nuclear Magnetic Resonance (¹H NMR) Liquid Chromatography-Mass Spectrometry (LC-MS) Structure-Activity Relationship (SAR) Bioactive compounds Novel derivatives Antimicrobial evaluation Drug discovery Pyridine derivatives Thiadiazole derivatives Nitroaniline derivatives Isatin derivatives Pharmaceutical chemistry

"Design, Synthesis, Characterization, and Evaluation of Novel Heterocyclic Derivatives with Potential Biological Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 2, page no.d331-d375, February-2026, Available :http://www.jetir.org/papers/JETIR2602345.pdf

"Design, Synthesis, Characterization, and Evaluation of Novel Heterocyclic Derivatives with Potential Biological Activities", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 2, page no. ppd331-d375, February-2026, Available at : http://www.jetir.org/papers/JETIR2602345.pdf