• Dr. Amit Shankar Shinde
• Dr.Hiteshwar D. Lonare

Drug-induced immunosuppression has emerged as a major clinical challenge due to the extensive use of corticosteroids, immunomodulators, chemotherapeutic agents, and biologics in modern medical practice⁴,⁵. Prolonged administration of these drugs leads to suppression of immune responses, resulting in increased susceptibility to infections, delayed wound healing, metabolic disturbances, and systemic debility⁴. In Ayurveda, such a condition can be correlated with Ojokshaya, Bala Kshaya, and Vyadhikshamatva Hani, where depletion of Ojas—the essence of all Dhatus—leads to compromised immunity and vitality¹,². Ayurveda defines immunity as an integrated function of Agni, Ojas, Bala, and equilibrium of Doshas and Dhatus¹,³. This review critically analyzes drug-induced immunosuppression through modern biomedical concepts and correlates them with Ayurvedic principles such as Tikshna Virya, Visha-sadrusha Guna, Agni Dushti, and Dhatu Kshaya¹,². Ayurvedic management strategies including Rasayana Chikitsa, Panchakarma, dietary regulation, herbal immunomodulators, and lifestyle interventions are discussed in detail¹,³,⁶,⁷. The article highlights Ayurveda’s potential as a supportive and restorative system in managing drug-induced immunosuppression while improving overall health and resilience.

Drug-induced immunosuppression, Ojas, Bala, Rasayana, Panchakarma, Vyadhikshamatva, Ayurveda

"AYURVEDIC APPROACHES OF DRUG-INDUCED IMMUNOSUPPRESSION THROUGH AGAD TANTRA PRINCIPLES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 3, page no.c370-c373, March-2026, Available :http://www.jetir.org/papers/JETIR2603247.pdf

"AYURVEDIC APPROACHES OF DRUG-INDUCED IMMUNOSUPPRESSION THROUGH AGAD TANTRA PRINCIPLES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 3, page no. ppc370-c373, March-2026, Available at : http://www.jetir.org/papers/JETIR2603247.pdf