• Dr. Reetu Sangwan
• Dr. Naz perween alam

Benzimidazole and its analogs belong to important class of bioactive heterocycles in the field of medicinal chemistry. The 5,6-dimethyl-1-(a-D-ribofuranosyl)benzimidazole ring system was discovered in 1948 as an integral part of the structure of vitamin B12. By retrosynthetic analysis we synthesized total sixteen novel benzimidazole analogs along with the synthesis of two known benzimidazole analogs 4 and 5 precursors and two series (7a-7h and 8a-8h) of eight analogs each and screened all the synthesized analogs for antioxidant (free radical scavenging activity) and antibacterial activity out of them only 8a with phenyl substituent and 8g with 3,5-dinitrophenyl substituent showed the highest free radical scavenging activity with % inhibition 98.73 % and 98.91 % as compared to standard BHT (99.24 %) at 100 g/ml concentration. In the evaluation of antibacteraial activity it was found that all the novel analogs (7a-7h and 8a-8h) were moderately active against all five bacterial strains viz. Agrobacterium tumefaciens (gram -ve), Erwinia chrysanthemi (gram -ve), Xanthomonas phaseoli (gram -ve), Escherichia coli (gram -ve) and Bacillus subtilis (gram +ve) with standard antimicrobial agent streptomycin.

Antimicrobial, Antioxidant, Benzimidazole, DPPH.

"Synthesis, characterization and Biological Evaluation of Benzimidazole Analogs", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 4, page no.a187-a201, April-2026, Available :http://www.jetir.org/papers/JETIR2604023.pdf

"Synthesis, characterization and Biological Evaluation of Benzimidazole Analogs", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 4, page no. ppa187-a201, April-2026, Available at : http://www.jetir.org/papers/JETIR2604023.pdf