• Paridhi Thakur
• Dr. Vivek Jain

Proposed method was found to be linear in the range of 5-25 μg/ml Ziprasidone with the correlation coefficient near to one respectively. The validation and the reliability of proposed method were assessed by recovery study. The recovery of added standards (80%, 100% 120%) was ranging from 99.62 to 99.784%, for Ziprasidone. Liquid chromatographic system from waters comprising of manual injector, Waters 515 binary pump for constant flow and constant pressure delivery and U.V. detector connected to data ace software controlling the instrumentation as well as processing methanol: Acetonitrile in the ratio of 50:50 v/v at a flow rate of 1.0 ml min-1. A thermo C-18 column (4.6 x 250mm, 5μ particle size) was used as the stationary phase, 250.0 nm was selected as the detection wavelength for UV-vis. detector. The proposed methods were found to be linear in the range of 5-25 μg/ml with correlation coefficient close to one. Precision was determined by repeatability, Intermediate precision and reproducibility of the drugs. The robustness of developed method was checked by changing in the deliberate variation in solvent. The result obtained shows the developed methods to be Cost effective, Rapid (Short retention time), Simple, Accurate (the value of SD and %RSD less than 2), Precise and can be successfully employed in the routine analysis of these drugs in bulk drug as well as in tablet dosage form.

Ziprasidone, Method development, Validation, HPLC, Dosage form.

"Method Development and Validation for Estimation of Ziprasidone in marketed formulation by using RP-HPLC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 9, page no.a750-a770, September-2026, Available :http://www.jetir.org/papers/JETIR2609095.pdf

"Method Development and Validation for Estimation of Ziprasidone in marketed formulation by using RP-HPLC", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 9, page no. ppa750-a770, September-2026, Available at : http://www.jetir.org/papers/JETIR2609095.pdf