• Dr. Medini Acharya
• Dr. Manjunatha Bhat

Wound healing remains a central clinical concern across surgical and general practice, and the search for agents that are both safe and multi-mechanistic continues to drive interest in traditional plant-based therapeutics. Yashtimadhu (Glycyrrhiza glabra Linn., family Fabaceae), known in classical Ayurvedic literature as Madhuka, Yashti and Klitanaka, has been used for over four millennia and occupies a distinct place among Vranaropana (wound-healing) and Sandhaniya (tissue-uniting) drugs described by Charaka, Sushruta and Vagbhata. Ayurveda attributes its therapeutic action to a Madhura Rasa, Guru-Snigdha Guna, Sheeta Virya and Madhura Vipaka, culminating in a Vata-Pitta Shamaka effect that is considered ideal for Sadyovrana (acute traumatic wounds). Contemporary pharmacological research substantiates this classical positioning: root extracts and their principal constituents-glycyrrhizin, 18β-glycyrrhetinic acid, liquiritin, isoliquiritigenin and glabridin-demonstrate anti-inflammatory, antimicrobial, antioxidant, immunomodulatory and pro-proliferative actions that collectively address the haemostatic, inflammatory, proliferative and remodelling phases of wound repair. Preclinical excision, incision and burn-wound models, together with in-vitro scratch-assay and cell-migration studies, report accelerated epithelialisation, enhanced collagen deposition and reduced microbial bioburden with topical licorice preparations. Clinically, Yashtimadhu-based formulations-most notably Yashtimadhu Ghrita and Yashtimadhu Taila-have shown favourable outcomes in postoperative, traumatic and chronic (Dushta Vrana) wounds, including diabetic ulcers, when used alone or as an adjunct. This review consolidates the Ayurvedic pharmacodynamic rationale and the available preclinical and clinical evidence on Yashtimadhu in wound healing, and outlines gaps-standardisation, dosage optimisation and rigorously designed clinical trials-that must be addressed before the drug can be more widely integrated into evidence-based wound-care protocols.

Yashtimadhu; Glycyrrhiza glabra; Licorice; Vranaropana; Sadyovrana; Wound healing; Glycyrrhizin; Ayurveda

"Yashtimadhu (Glycyrrhiza glabra) in Wound Healing: A Review Bridging Ayurvedic Pharmacodynamics and Contemporary Pharmacological Evidence", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 9, page no.c643-c649, September-2026, Available :http://www.jetir.org/papers/JETIR2609270.pdf

"Yashtimadhu (Glycyrrhiza glabra) in Wound Healing: A Review Bridging Ayurvedic Pharmacodynamics and Contemporary Pharmacological Evidence", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 9, page no. ppc643-c649, September-2026, Available at : http://www.jetir.org/papers/JETIR2609270.pdf