• Dr. Rina Popatrao Deshmukh
• Dr MAnisha Potekar

Background: Insulin resistance is increasingly recognized as a central, driving factor in the pathogenesis of type 2 diabetes mellitus, often detectable ten to twenty years before overt disease manifests. Despite its established predictive value, the precise mechanisms underlying its development remain incompletely understood. One proposed contributing mechanism involves obstruction within the body's microcirculatory channels, a phenomenon that finds a notable conceptual parallel in the Ayurvedic understanding of Srotorodha. Aim: This review sets out to examine Srotorodha, a state of channel obstruction linked to the accumulation of Ama (improperly metabolized toxic byproducts), and to explore its possible association with the pathogenesis of insulin resistance. Methodology: Classical Ayurvedic texts including the Charak Samhita, Sushruta Samhita, and Ashtanga Hridaya with their respective commentaries were reviewed alongside standard Ayurvedic textbooks to build an understanding of Srotorodha and Ama. In parallel, contemporary scientific literature was searched across databases including PubMed, the Cochrane Library, BioMed Central, IndMED, and Google Scholar to compile relevant findings on the physiology and mechanisms of insulin resistance. Data from both streams were compiled and synthesized into a narrative review. Discussion: Ama, understood as undigested or improperly transformed metabolic material, accumulates within the body's channels and manifests clinically as Srotorodha, alongside associated features such as Bala Bhramsha, Gaurava, Aalasya, and Apakti. From a physiological standpoint, insulin resistance similarly involves impaired glucose and insulin delivery to target tissues, with microvascular blood flow and capillary recruitment playing a key regulatory role in glucose disposal. Srotorodha may parallel this defect by obstructing minute channels, thereby impairing the reception, absorption, and assimilation of insulin and glucose at the tissue level. Elevated blood glucose and consequent hyperinsulinemia may further worsen Srotorodha, perpetuating a self-reinforcing cycle of metabolic dysfunction. Conclusion: Srotorodha, as a hallmark clinical sign of Ama accumulation, may represent a contributing factor in the development of insulin resistance. A treatment approach targeting Srotorodha at an early stage could offer a valuable therapeutic strategy, helping to interrupt this cycle and providing a foundation for novel, Ayurveda-informed approaches to preventing and managing type 2 diabetes.

Insulin resistance, Srotorodha, Ama, type 2 diabetes, Ayurveda, Srotovaigunya

""Srotorodha as a Contributing Factor in Insulin Resistance: A Critical Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 9, page no.d206-d211, September-2026, Available :http://www.jetir.org/papers/JETIR2609323.pdf

""Srotorodha as a Contributing Factor in Insulin Resistance: A Critical Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 9, page no. ppd206-d211, September-2026, Available at : http://www.jetir.org/papers/JETIR2609323.pdf