• Dr. Sharad G. Funde
• Sharad T Gavhane
• Utkarsh B. Funde

Antimicrobial resistance (AMR) has emerged as one of the most serious global public health challenges, threatening the effective prevention and treatment of infectious diseases. The widespread misuse and overuse of antimicrobial agents in human medicine, agriculture, and animal husbandry have accelerated the development of resistant pathogens, rendering many conventional antibiotics ineffective. As a result, there is an urgent need for the development of new and innovative antimicrobial therapies to address this growing crisis. This review highlights recent advances in antimicrobial drug development aimed at combating resistance. Novel antibiotics with unique mechanisms of action, along with improved derivatives of existing drugs, have shown promise against multidrug-resistant pathogens. Emerging approaches such as antimicrobial peptides, bacteriophage therapy, nanotechnology-based delivery systems, and CRISPR-Cas gene-editing technologies offer innovative alternatives to traditional treatments. Additionally, strategies like drug repurposing, combination therapy, and the application of artificial intelligence (AI) have accelerated the identification and optimization of potential antimicrobial agents. Despite these advancements, several challenges persist, including resistance evolution, safety concerns, limited clinical data, and issues related to accessibility and affordability. Addressing these barriers requires sustained research efforts, supportive regulatory frameworks, and global collaboration. Significant progress has been made, combating AMR demands a multifaceted approach that integrates scientific innovation, responsible antimicrobial use, and international cooperation. Future research should focus on developing effective, safe, and accessible therapies to ensure long-term control of AMR and the continued success of modern medicine.

Antimicrobial resistance, Drug development, AMR, Novel antibiotics, Antimicrobial peptides, Nanotechnology

"Recent Advances in Antimicrobial Drug Development to Combat Antimicrobial Resistance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 10, page no.a101-a116, October-2026, Available :http://www.jetir.org/papers/JETIR2610011.pdf

"Recent Advances in Antimicrobial Drug Development to Combat Antimicrobial Resistance", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 10, page no. ppa101-a116, October-2026, Available at : http://www.jetir.org/papers/JETIR2610011.pdf