• Pankaj Yadav
• Aditya Pandey
• Mrs. Mandvi Tiwari
• (Pro) Dr. Arvind Kumar Srivastava

Diuretic agents play crucial role in the management of disorders as with excessive fluid retention and altered electrolyte homeostasis. Although conventional diuretics are highly effective, their use mey be lectrolyte disturbance and other side effect, creating continued interest in medicinal plants as potential sources of pharmacologically active compounds. Pogostemon purpurascens Dalzell, belonging to the family Lamiaceae, is a medicinal herb and found in Western Ghats. The species has been documented from Karnataka and adjoining regions and is traditionally associated with several medicinal applications. Phytochemical investigations of P. purpurascens have demonstrated the presence of bioactive classes including alkaloids, flavonoids, phenolic compounds, tannins, coumarins and terpenoids. A methoxylated flavonoid, 3,5,6,7,8,2′,4′,5′-octamethoxyflavone, has also been reported from the species. The presence of these phytoconstituents provides a pharmacological basis for investigating the renal effects of the plant, particularly modulation of urinary water and electrolyte excretion. Flavonoids and phenolic constituents present in medicninal plant hve been their investigated for their effects on renal vascular function, oxidative stress, tubular transport and related signaling pathways; however, so mechanisms should not be directly attributed to P. purpurascens without species-specific experimental confirmation. The available literature indicates that research on P. purpurascens has predominantly focused on phytochemical characterization, antimicrobial properties and traditional medicinal applications, whereas systematic evaluation of its diuretic activity remains insufficiently explored. This review therefore examines the botanical characteristics, geographical distribution, traditional relevance, phytochemical composition and pharmacological rationale for investigating the diuretic potential of P. purpurascens leaves. A particular urinary sodium and potassium excretion, diuretic index and related parameters using established animal models. The available evidence suggests that P. purpurascens represents an interesting candidate for further pharmacological investigation; nevertheless, its diuretic efficacy, moa, and dose-response in relationship and safety profile require systematic validation through well-controlled preclinical studies.

Diuretic agents play crucial role in the management of disorders as with excessive fluid retention and altered electrolyte homeostasis. Although conventional diuretics are highly effective, their use mey be lectrolyte disturbance and other side effect, creating continued interest in medicinal plants as potential sources of pharmacologically active compounds. Pogostemonpurpurascens Dalzell, belonging to the family Lamiaceae, is a medicinal herb and found in Western Ghats. The species has been documented from Karnataka and adjoining regions and is traditionally associated with several medicinal applications. Phytochemical investigations of P. purpurascens have demonstrated the presence of bioactive classes including alkaloids, flavonoids, phenolic compounds, tannins, coumarins and terpenoids. A methoxylated flavonoid, 3,5,6,7,8,2′,4′,5′-octamethoxyflavone, has also been reported from the species. The presence of these phytoconstituents provides a pharmacological basis for investigating the renal effects of the plant, particularly modulation of urinary water and electrolyte excretion. Flavonoids and phenolic constituents present in medicninal plant hve been their investigated for their effects on renal vascular function, oxidative stress, tubular transport and related signaling pathways; however, so mechanisms should not be directly attributed to P. purpurascens without species-specific experimental confirmation. The available literature indicates that research on P. purpurascens has predominantly focused on phytochemical characterization, antimicrobial properties and traditional medicinal applications, whereas systematic evaluation of its diuretic activity remains insufficiently explored. This review therefore examines the botanical characteristics, geographical distribution, traditional relevance, phytochemical composition and pharmacological rationale for investigating the diuretic potential of P. purpurascens leaves. A particular urinary sodium and potassium excretion, diuretic index and related parameters using established animal models. The available evidence suggests that P. purpurascens represents an interesting candidate for further pharmacological investigation; nevertheless, its diuretic efficacy, moa, and dose-response in relationship and safety profile require systematic validation through well-controlled preclinical studies.

"Pharmacological Evaluation of the Diuretic Potential of Pogostemon purpurascens Dalzell Leaves Exploring the Potential for Diuretic Modulation: Review Paper", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.13, Issue 10, page no.b427-b433, October-2026, Available :http://www.jetir.org/papers/JETIR2610144.pdf

"Pharmacological Evaluation of the Diuretic Potential of Pogostemon purpurascens Dalzell Leaves Exploring the Potential for Diuretic Modulation: Review Paper", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.13, Issue 10, page no. ppb427-b433, October-2026, Available at : http://www.jetir.org/papers/JETIR2610144.pdf