• S.HAMEED KADAR ALI

Objective: To study the effect of alpha lipoic acid in reducing oxidative stress induced in acute amytriptyline poisoning cases. Design and methods: We compared the effect of supplementation of treatment of poisoning cases with alpha lipoic acid alone or with vitamin C, with that of those receiving only routine standard treatment for poisoning and that of a healthy control group. Result: A determination of the level of creatine kinase (CK) and cholinesterase (chE) (indirect indicators of oxidative stress) in both the supplemented and the non supplemented group was done. A decrease in the level of oxidative stress was observed among those supplemented with either alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in oxidative stress in the later group. Conclusion: The results provide evidence that the oxidative stress induced by acute amytriptyline poisoning is comparatively decreased by supplementation with antioxidants like alpha lipoic acid and Vitamin C, than those only on routine standard treatment.

Alpha lipoic acid (ALA), Vitamin C, Acetyl cholinesterase (AchE), Creatine kinase (CK),

"OXIDATIVE STRESS IN ACUTE ANTI-PSYCHOTROPIC DRUG POISONING, AND THE EFFECT OF ANTIOXIDANTS ON CHOLINESTERASE LEVELS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 9, page no.24-30, September-2018, Available :http://www.jetir.org/papers/JETIRA006327.pdf

"OXIDATIVE STRESS IN ACUTE ANTI-PSYCHOTROPIC DRUG POISONING, AND THE EFFECT OF ANTIOXIDANTS ON CHOLINESTERASE LEVELS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 9, page no. pp24-30, September-2018, Available at : http://www.jetir.org/papers/JETIRA006327.pdf