UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 5 Issue 9
September-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRA006327


Registration ID:
189145

Page Number

24-30

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Title

OXIDATIVE STRESS IN ACUTE ANTI-PSYCHOTROPIC DRUG POISONING, AND THE EFFECT OF ANTIOXIDANTS ON CHOLINESTERASE LEVELS

Abstract

Objective: To study the effect of alpha lipoic acid in reducing oxidative stress induced in acute amytriptyline poisoning cases. Design and methods: We compared the effect of supplementation of treatment of poisoning cases with alpha lipoic acid alone or with vitamin C, with that of those receiving only routine standard treatment for poisoning and that of a healthy control group. Result: A determination of the level of creatine kinase (CK) and cholinesterase (chE) (indirect indicators of oxidative stress) in both the supplemented and the non supplemented group was done. A decrease in the level of oxidative stress was observed among those supplemented with either alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in oxidative stress in the later group. Conclusion: The results provide evidence that the oxidative stress induced by acute amytriptyline poisoning is comparatively decreased by supplementation with antioxidants like alpha lipoic acid and Vitamin C, than those only on routine standard treatment.

Key Words

Alpha lipoic acid (ALA), Vitamin C, Acetyl cholinesterase (AchE), Creatine kinase (CK),

Cite This Article

"OXIDATIVE STRESS IN ACUTE ANTI-PSYCHOTROPIC DRUG POISONING, AND THE EFFECT OF ANTIOXIDANTS ON CHOLINESTERASE LEVELS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 9, page no.24-30, September-2018, Available :http://www.jetir.org/papers/JETIRA006327.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"OXIDATIVE STRESS IN ACUTE ANTI-PSYCHOTROPIC DRUG POISONING, AND THE EFFECT OF ANTIOXIDANTS ON CHOLINESTERASE LEVELS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 9, page no. pp24-30, September-2018, Available at : http://www.jetir.org/papers/JETIRA006327.pdf

Publication Details

Published Paper ID: JETIRA006327
Registration ID: 189145
Published In: Volume 5 | Issue 9 | Year September-2018
DOI (Digital Object Identifier):
Page No: 24-30
Country: --, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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