UGC Approved Journal no 63975(19)

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Published in:

Volume 5 Issue 9
October-2018
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRA006364


Registration ID:
189255

Page Number

259-261

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Title

A NOBLE AND INNOVATIVE SOLUTION TO BLOOD SHORTAGE

Abstract

Review of literature has showed that there is a high demand for type “O” blood. Type-o positive is the most transfused blood type as it can be given to any patients with RH positive blood type due to absence of antigens and presence of both antibodies. Meanwhile type o-negative is a universal donor and can be given to patient of any blood type due to the absence of any kind of antigens. The eight different blood types that can be categorized into four groups based on their antigens: A, B, AB, and O with the help of presence on antigens and antibodies which are responsible for the detection of the foreign objects and deal with it. Our aim was to convert the AB blood group to O blood group. Thus it can be safely transfused to anyone without any risk. We have extracted the total DNA from human gut using metagenomics and expressed in E. coli. It eventually led to focus on the mucosal lining of the human gut, which contains sugars that similar in structure to blood antigens. They were then able to “use E. coli to select for DNA containing genes that code for enzymes that can cleave sugar residues.” then multiple the enzymes and found that it was capable of removes the Gal or Gal-NAc residues that determine the antigens of type-A and type-B blood, which essentially makes the blood type-O.2) select specific glycoside hydrolase families of interest and create a phylogenetically distinct sub-families of their genes. From each sub-family select a representative gene and expressed it in E.coli.

Key Words

Blood Group, E.coli, Human Gut, Metagenomics, Phylogenetics

Cite This Article

"A NOBLE AND INNOVATIVE SOLUTION TO BLOOD SHORTAGE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 9, page no.259-261, October-2018, Available :http://www.jetir.org/papers/JETIRA006364.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A NOBLE AND INNOVATIVE SOLUTION TO BLOOD SHORTAGE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 9, page no. pp259-261, October-2018, Available at : http://www.jetir.org/papers/JETIRA006364.pdf

Publication Details

Published Paper ID: JETIRA006364
Registration ID: 189255
Published In: Volume 5 | Issue 9 | Year October-2018
DOI (Digital Object Identifier):
Page No: 259-261
Country: --, -, - .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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