• Dr. ManshaKotwani
• Neeru Adlakha

Fibroblasts are activated and migrated to the wound sites during an injury or inflammation to repair the tissue. Calcium release and calcium influx both have been linked to cell migration depending upon cell type and stimuli. In mouse embryonic fibroblast (MEF) the calcium influx is mediated by L-type calcium channels, which plays an important role in PDGF- induced cell migration in fibroblast. In order to understand the dynamics of calcium transient in complex biological processes, a mathematical model has been developed for two dimensional unsteady state case. The main objective of this work is to study the effect of L-type calcium channel and cytosolic buffers on calcium dynamics in fibroblast cell. The important parameters channel permeability, buffer concentration, buffer binding affinity have been incorporated in the model. Finite difference method has been employed to obtain the solution. Appropriate boundary conditions have been framed along with physiology of the cell. This model can be used to study the complex mechanisms of wound repair and tissue remodeling performed by the fibroblast cell.

L-type calcium channel, buffer binding affinity, finite difference method, channel permeability.

"Calcium Diffusion Study with Interplay of Channels and Pumps in Fibroblast Cell Using Finite Difference Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.128-134, March-2019, Available :http://www.jetir.org/papers/JETIRAL06029.pdf

"Calcium Diffusion Study with Interplay of Channels and Pumps in Fibroblast Cell Using Finite Difference Method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp128-134, March-2019, Available at : http://www.jetir.org/papers/JETIRAL06029.pdf