• Ms. Anusha Devi Maran
• D. Raja Sudhakar

Ovarian and endometrium cancers are the fifth most common diagnosed cancers in India. As per 2020 statistics, it may lead to third most common diagnosed cancers in India. Overexpression or mutation of Leucine Zipper-like Transcription Regulator1 (LZTR1) leads to varies cancer such as schwannomas, melanoma, prostate cancer and endometrial cancer. LZTR1 protein is a member of BTB-Kelch superfamily which is involved in DNA-binding transcription factor activity. The sequence of LZTR1 (Q8N653) comprises of 840 amino acids whose structure is yet to be determined. In this study, we predicted the tertiary structure of LZTR1 using fold recognition or threading method through I-TASSER server and predicted potential phytochemical anti-cancerous inhibitors from NPACT database against LZTR1 protein by virtual screening through PyRx software. Phytochemical compounds such as Dinoxin B (NPACT00510), Luxenchalcone (NPACT00730) and Paclitaxel (NPACT00839) shown better interactions against LZTR1 protein with the binding affinity of -9.4 kcal/mol.

LZTR1, Ovarian cancer, Endometrial cancer, NPACT, I-TASSER, PyRx

"Prediction of potential phytochemical anti-cancerous compounds against Leucine Zipper Transcription Regulator-1 (LZTR1) through In silico analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.356-359, March-2019, Available :http://www.jetir.org/papers/JETIRAL06075.pdf

"Prediction of potential phytochemical anti-cancerous compounds against Leucine Zipper Transcription Regulator-1 (LZTR1) through In silico analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp356-359, March-2019, Available at : http://www.jetir.org/papers/JETIRAL06075.pdf