• P. R. Mahajan

The present study describes antioxident effect of caffeine (1,3,7-Trimethlaxanthine) against copper sulphate induced histopathological alteration on hepatopancreas in an experimental model, the fresh water bivalve,Lamellidens consobrinus. The effect of CuSO4 and caffeine were studied under three groups. Group A bivalves was maintained as control, Group B was exposed to chronic LC 50/10 doses of copper sulphate (2.12 ppm) for 18 days, while group C bivalves were exposed to respective chronic concentrations of heavy metals with 5 ml/lit caffeine. The changes are observed at 6, 12 and 18 days. In hepatopancreatic structure showed more disintegration of basement membrane due to damaged epithelial cells, disruption of hepatic tubules, and increase in internal luminar area in bivalves exposed to copper sulphate as compared to those exposed in copper sulphate along with caffeine.The probable antioxident role of caffeine is discussed in the paper.

- Lamellidens consobrinus, Copper sulphate, Hepatopancreas, Histopathological alterations, Caffeine

" CURATIVE ROLE OF CAFFEINE ON COPPER INDUCED HISTOPATOLOGICAL ASSESMENT OF HEPATOPANCREATIC CELLS IN FRESH WATER BIVALVE, LEMELLIDENS CONSOBRINUS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.439-444, March-2019, Available :http://www.jetir.org/papers/JETIRAO06065.pdf

" CURATIVE ROLE OF CAFFEINE ON COPPER INDUCED HISTOPATOLOGICAL ASSESMENT OF HEPATOPANCREATIC CELLS IN FRESH WATER BIVALVE, LEMELLIDENS CONSOBRINUS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp439-444, March-2019, Available at : http://www.jetir.org/papers/JETIRAO06065.pdf