• Gautam P. Sadawarte

Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drugs research and development endeavor. Diabetes Mellitus is associated with impaired glucose metabolism that leads to increases blood glucose level and free radicals production. Unfortunately none of the present drug in management of metabolic disorder is unimpeachable. Metaformin increases the risk of lactic acidosis, Sulphonylureas result in hypoglycemia and Acarbose increases flatulence and bloating. A new series of chalcone was prepared. The reaction of substituted benzaldehyde with different acetophenone and alcoholic KOH. The purity of new compound was cheak by TLC and their structure confirmed by IR and H1NMR.The target compound evaluated for their biological properties.

Antidiabetic activity, chalcone, diabetes mellitus.

"Synthesis and Evaluation of different 3-substituted chalcone with Screen their biological properties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.486-490, March-2019, Available :http://www.jetir.org/papers/JETIRAO06072.pdf

"Synthesis and Evaluation of different 3-substituted chalcone with Screen their biological properties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp486-490, March-2019, Available at : http://www.jetir.org/papers/JETIRAO06072.pdf