• Sathishkumar R
• Sree Ram S.

Genetic disorders are increasing by recent years due to exposure to harmful radiations and mutations in the gene sequence due to the period of time evolution, and also depends on one person’s life. Genetic disorders are increasing by recent years due to exposure to harmful radiations and mutations in the gene sequence due to the period of time evolution, and also depends on one person’s life. The genetic disorder Creutzfeldt-Jakob disease (CJD) is a human degenerative disease and has four categories, sporadic, familial, iatrogenic and variant. CJD is a type of transmissible spongiform encephalopathies (TSEs) or prion disease. The abnormal prions PrPSc were observed with similar aminoacid sequences with normal cellular prions PrPC, which implicated that mutated genes responsible for PrPC replicates itself and spontaneously changes its shape into infectious form. The rate of mutation and variation defines the disease type, however, it is defined that the population with mutated prion may not develop the diseased condition. Medicinal plants and their secondary metabolites were analyzed through docking studies and predicted for ADME properties. The chemical compound Catechin/cianidanol had a much significant G.score value of -8Kcal/ol and the interactions with active site residues GLN-160, GLN-186, TYR-157, ASN-159, THR-190.

Creutzfeldt-Jakob disease (CJD); Prion Protein; catechin; Molecular docking analysis, Medicinal plants

"MOLECULAR DOCKING ANALYSIS OF SELECTED MEDICINAL PLANTS FOR TREATING GENETIC DISORDER- CJD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.25-29, May-2019, Available :http://www.jetir.org/papers/JETIRBK06005.pdf

"MOLECULAR DOCKING ANALYSIS OF SELECTED MEDICINAL PLANTS FOR TREATING GENETIC DISORDER- CJD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp25-29, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06005.pdf