• Sathish Kumar
• Tharani

Hemochromatosis is a hereditary defect are the patient’s incapability to prevent the excess iron entering the bloodstream and accumulates in parenchymatous organs. It was identified that the loss of gene responsible for the enzyme hepcidin, an iron hormone produced in the liver results in paradigmatic iron-loading disorder. India has a vast diversity of plants, perhaps from our ancient times medicinal plants have a significant role in maintaining the health. Utilization of medicinal plants in the field of medicine has been appreciated by World Health Organization (WHO) and 80% of human population are depend in the developing countries. The present study focused on plants like Aeridescrispum, Aeridesodoratum, Agrostophyllum callosum, Arundinagramnifolia, Bulbophyllumodoratissimum, Cephalantheropsisgracilis, Coelogynecristata, Dendrobiumnobile, Eulophianuda, Gastrodiaelata and Habenariarepens and their phytochemical compounds reported to be present are retrieved from the PubChem database. The in silico techniques were utilized to analyze the compounds for its absorption, distribution, metabolism and excretion property as well as its efficiency in interacting with the target protein of PDB ID: 1M4E. The docking study was determined using Glide module of Schrodinger software and it was observed that the compound moscatilin had significant G.score and interaction with the protein.

Hemochromatosis, Medicinal Plants, Defective Hepcidin, Docking studies, Moscatilin

"In silico Determination of Plant Compounds in the Treatment of Hemochromatosis- A Hereditary Genetic Iron Disorder Syndrome", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.30-36, May-2019, Available :http://www.jetir.org/papers/JETIRBK06006.pdf

"In silico Determination of Plant Compounds in the Treatment of Hemochromatosis- A Hereditary Genetic Iron Disorder Syndrome", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp30-36, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06006.pdf