• Mahendran Radha
• Jeyabasker Suganya
• SharanyaManoharan
• Amrutha.P.Murugan
• Dhananya.S

Tuberculosis (TB) is an infectious airborne disease caused by the Pathogen Mycobacterium tuberculosis. It is the major cause of human mortality rate from a curable infectious disease, attacking mainly in developing countries. Vaccination against tuberculosis is available but proved to be unsuccessful against emerging multidrug and extensive drug resistant bacterial strains. This in turn raises the pressure to speed up the research on developing new and more efficient anti-tuberculosis drugs. There is a growing focus on the importance of medicinal plants to cure these type of infectious disease. Anisomeles malabarica is perhaps the most useful traditional medicinal plant. Thus, the development of a plant- based antibacterial preparation promises a more potential alternative when compare to synthetic drugs against Tuberculosis. The pharmacological studies of Anisomeles malabarica had revealed that it possess antibacterial activity and huge potential to cure Tuberculosis. The 34 phytochemical compounds from Anisomeles malabarica were identified through literature survey and also the protein Lex A repressor and Hypothetical protein Rv0098 of the strain H37Rv with the PDB ID 2PFC, 6A2Q were identified to be more pathogenic and responsible for Tuberculosis disease in human. We carried out Molecular Docking studies for the above 34 Compounds and 2 Proteins. Docking was performed for both synthetic compounds and Anisomeles compounds. After Comparative studies the best docking interactions were reported. Finally through our current study we identified that the above 2 proteins interacting with Anisomeles compounds showed best results while comparing with synthetic compounds interaction.

Tuberculosis, Anisomeles malabarica, Antibacterial studies, phytochemical compounds, Docking.

"Comparative Insilico Analysis and Identification of Anisomeles derived inhibitors against Lex A repressor & Rv0098 of H37Rv-Mycobacterium tuberculosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.61-66, May-2019, Available :http://www.jetir.org/papers/JETIRBK06011.pdf

"Comparative Insilico Analysis and Identification of Anisomeles derived inhibitors against Lex A repressor & Rv0098 of H37Rv-Mycobacterium tuberculosis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp61-66, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06011.pdf