• Jeyabaskar Suganya
• Mahendran Radha
• Sharanya M
• Chandra Choodan

Rutin, a bioflavonol compound was one of vital nutritional component present in many medicinal plants and exhibit a several pharmacological property. Diabetes is one of the most serious metabolic disorders across the world which affects all age groups. According to World Health Organization (WHO), more than 230 million individuals were affected worldwide by diabetes; they also expected that it will reach upto 350 million by end 2025. Currently in India more than 62 million individuals were diagnosed by diabetes, therefore there is an urgent need for the discovery of novel natural anti-diabetic drugs without any side effects. The present study was designed in order to evaluate its binding efficiency with anti-diabetic protein target protein tyrosine phosphates (PTP) through in silico studies. The function of Insulin receptor, the protein tyrosine phosphatase was to the remove the phosphate group from the tyrosine amino acid which was present in the functional region thereby decreasing the production of insulin. The crystal structure of protein tyrosine phosphate was selected as target from the protein data bank and further docking studies were performed using Argus lab software. Among the 14 protein structure of protein tyrosine phosphatase, the compound rutin exhibited significant binding energy with 2BO7 and also exhibited the better binding affinity with other protein structures. The future studies could be designed accordingly to highlight the efficiency of rutin towards drug development in the treatment of diabetes.

Diabetes, Rutin, Protein Tyrosine Phosphates, Molecular Docking.

"COMPARATIVE INSILICO DOCKING STUDIES OF RUTIN AS DIABETIC INHIBITOR AGAINST PROTEIN TYROSINE PHOSPHATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.101-105, May-2019, Available :http://www.jetir.org/papers/JETIRBK06018.pdf

"COMPARATIVE INSILICO DOCKING STUDIES OF RUTIN AS DIABETIC INHIBITOR AGAINST PROTEIN TYROSINE PHOSPHATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp101-105, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06018.pdf