• Jeyabaskar Suganya
• Mahendran Radha
• Rajesh Kumar. G

Diabetes Mellitus is a chronic metabolic disorder with altered carbohydrate, lipid and protein metabolism due to insufficient amount of insulin secretion by the organ pancreasin the human body. The synthesis of currently available anti-diabetic drugs like metformin, sulfonylureas etc., are mainly by the combination of artificial chemical molecules which lead to the various adverse effects. In recent years, the scientists have turned their attention towards the medicinal plants which bears the rich source of metabolites which offer specific physiological function in the human body without any adverse effect. Through literature, it was confirmed that in the olden days the bark, leaf, fruits, seeds of the plant Sterculia foetida were used as the medicine without the knowledge the actual bioactive molecules present in the parts of the plant. Among the various parts of the plant Sterculia foetida, the leaves bears various pharmacological activity and the current study elicited that the methanol leaf extract of Sterculia foetida were subjected to invitro antidiabetic activity by α-amylase enzymes and α-glucosidase enzymes against the standard acarbose. The result of the study provided us the strong proof that the glucose level was gradual decrease in the methanol leaf extract by inhibiting the function of α-amylase and α-glucosidase enzymes when compared with the standard acarbose. The outcome of the current study will pay the way for next step of research in methanol leaf extract of Sterculia foetida in discovering the new diabetic lead molecule for drug designing.

Sterculia foetida, Methanol leaf extract, anti-diabetic activity, α-amylase enzyme, α-glucosidase enzyme.

"IN VITRO EVALUATION OF ANTIDIABETIC ACTIVITY OF THE METHANOL LEAF EXTRACT OF STERCULIA FOETIDA LINN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.111-115, May-2019, Available :http://www.jetir.org/papers/JETIRBK06020.pdf

"IN VITRO EVALUATION OF ANTIDIABETIC ACTIVITY OF THE METHANOL LEAF EXTRACT OF STERCULIA FOETIDA LINN.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp111-115, May-2019, Available at : http://www.jetir.org/papers/JETIRBK06020.pdf