• Syeda Nishat Fathima
• S. Vasudeva Murthy

Objective: The present study was designed to carry out acute oral toxicity of find out Rosa damascena petals as per Section 4 of Organization for Economic Cooperation and Development (OECD) 423 guideline Methods: Female Mice was administered ethanolic petal extract of Rosa damascena in a single dose by oral gavage at the volume of 1ml/100g of animal at the dose levels of 5, 50, 300, 2000 mg/kg body weight. Mice are observed individually after dosing at least once during the first 30 minutes, periodically during the first 24 hours, with special attention given during the first 4 hours and daily thereafter, for an overall of 14 days for mortality, wellness parameters and body weight.Results: The highest dose administered (2000 mg/kg body weight) did not produce mortality or changes in body weight and wellness parameters of the mice. Conclusion: The ethanolic petal extract of Rosa damascena is classified in class 5 (substance with LD50 higher than 2000 mg kg-1 and less than 5000 mg kg-1) and is being considered as having low toxicity.

Rosa damascena; Acute Oral Toxicity; OECD Guidelines 423; Lethality (LD50).

"EVALUATION OF ORAL ACUTE TOXICITY OF ETHANOLIC EXTRACT OF ROSA DAMASCENA PETALS AS PER OECD GUIDELINES 423", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.105-109, May-2019, Available :http://www.jetir.org/papers/JETIRBY06013.pdf

"EVALUATION OF ORAL ACUTE TOXICITY OF ETHANOLIC EXTRACT OF ROSA DAMASCENA PETALS AS PER OECD GUIDELINES 423", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp105-109, May-2019, Available at : http://www.jetir.org/papers/JETIRBY06013.pdf