• Priyaranjini S Rao
• Dr.Swarna M Patra
• Dr.Raviraj AKusanur

The present study deals with a systematic approach on synthesis, molecular docking and pharmacological activities associated with 5-ethyl pyridin-2-ethanol derivatives. Pioglitazone is an oral antidiabetic agent that has been developed by the derivatization of title compound. In addition numerous pharmaceutically active compounds of this class were reported timely, which possess diverse biological activities such as antimicrobial, antitumor, anticancer, anti-HIV and antibacterial with least adverse effects. Molecular docking on several reported phenoxy ethyl pyridine substituents are done with 5Y2T obtained from RSCB protein data bank. With reference to the above computational analysis, new moieties of 5-ethyl-2-(2-{4-[(E)-(2-substituted phenyl hydrazinylidene)methyl]phenoxy}ethyl)pyridine are designed and synthesized with characterization. The newly synthesized moieties exhibited promising biological activities in comparison with the selected reported drugs through docking studies.

Computational study, Antidiabetic activity, Molecular docking, Pioglitazone.HCl

"Computational Molecular Docking Analysis Of 5-ethyl pyridin-2-ethanol Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.398-401, May-2019, Available :http://www.jetir.org/papers/JETIRCD06069.pdf

"Computational Molecular Docking Analysis Of 5-ethyl pyridin-2-ethanol Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp398-401, May-2019, Available at : http://www.jetir.org/papers/JETIRCD06069.pdf