• Fathima Bee. K
• Lilly Hilda Mary A.
• Jamuna.J

The bioactive compounds of the peel and pulp of Carica papaya was extracted using Petroleum ether, ethyl acetate, and Methanol and investigated for the presence of secondary metabolites. All the three solvent extracts revealed the presence of alkaloids; Flavonoids, glycosides, and terpenoids were present in the peel and pulp. The bioactivities of the peel and pulp extracts were attributed to their phytochemical constituents. Antimicrobial activity of the extracts was determined using agar well diffusion method. In this present study, the petroleum ether extract has shown high zone of inhibition in Aspergillus Niger, Bacillus Subtitles, Candida albicans, Escherichia Coli, Enterococcus feacalis, Klebsiella phenomena, Pseudomonas aurogenosa Staphylococcus aureus, Staphylococcus zoopiepidermis, Vibro cholera, S, mutant. Ethyl acetate extract has shown a high zone of inhibition in Aspergillus Niger, C.albicans, E.auroges, P.auroges, E.feacalis, s.zoopiepidermis, Vibro cholera. Methanol extract has shown a high zone of inhibition in Aspergillus Niger, Candida albicans, E.coli, E. feacalis, E.aurogesS.aures, S.zoopiepidermis, S.mutant. When compared the zone of inhibition with the standard drugs like protoxin. Antioxidant activity was determined using the DPPH assay method and the absorbance measured using UV- visible spectrophotometer with ascorbic acid as control. The antioxidant activities of ethyl acetate showed more activity than the other two extracts. The ethyl acetate extract showed the antioxidant activity of 61.6% in DPPH assay. This study demonstrates the efficacy of petroleum ether peel and pulp extracts of Carica Papaya as an alternative antibiotic for the development of newer antibacterial agents.The anti-cancer activity was also determined. Breast cancer cell lines (MCF7) were used and cytotoxicity is studied using all three extracts. The result showed that there was a maximum 28% reduction in cell viability at the highest concentration tested. Ethyl acetate extract showed more toxicity to breast cancer cells than the other two extracts. The lowest cell viability against normal cells was 80 percent (ethyl acetate extract) while the cell viability.

EVALUATION OF BIOMEDICAL IMPORTANCE OF PAPAYA PULP

"EVALUATION OF BIOMEDICAL IMPORTANCE OF PAPAYA PULP ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.59-67, May-2019, Available :http://www.jetir.org/papers/JETIRCI06011.pdf

"EVALUATION OF BIOMEDICAL IMPORTANCE OF PAPAYA PULP ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp59-67, May-2019, Available at : http://www.jetir.org/papers/JETIRCI06011.pdf