• BATRA UNNATI
• TRIPATHI MEGHNA
• NAGARAJAN K
• JAGANNATH SAHOO

Hepatitis C viral infection is a major affecting liver disease most consistently found in users of drug by injection route. The transmission is attained by percutaneous or permucosal attainment to the blood infected with Hepatitis C viral infection. This type of infection occurs 20% acutely and around 70% chronically. The major concern for the disease is that it may or may not show any symptoms, fewer than half of those infected with HCV may be aware of their infection. Majorly this infection can be leading cause of hepatocellular carcinoma. clinical manifestations of HCV infection relate to various studies about HCV associated Hepatocellular carcinoma(secondary malignancies). The pathophysiology of the disease perfectly indicated the high risks towards cirrhosis at later stages. The diagnosis of the disease is poorly screened as HCV RNA cannot be detected easily in the blood. this is called sustained virological response. In the recent past USFDA approved two new protease inhibitors for the treatment of the disease. The future aspects in the field of creating a treatment lead to various approaches of new drug discovery through computational procedures.The future aspects including all the diagnostic and treatment procedures for hepatitis c virus infection have been introduced in this review in the elaborated way, which is a more challenge in terms of innovation & sustainable development in the area of drug discovery against hepatitis-C infection.

Cirrhosis,Hepatitis C Virus, Hepatocellular Carcinoma, Protease Inhibitors

"DIAGNOSIS, TREATMENT AND COMPUTATIONAL APPROACHES: HEPATITIS-C ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.102-106, June 2019, Available :http://www.jetir.org/papers/JETIRDH06016.pdf

"DIAGNOSIS, TREATMENT AND COMPUTATIONAL APPROACHES: HEPATITIS-C ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp102-106, June 2019, Available at : http://www.jetir.org/papers/JETIRDH06016.pdf