• Dr. Varsha S. Zade
• Prof. (Dr.) Shirish P. Deshmukh

A series of novel 4-aryl-3, 5-di-(o-tolylimino)-1, 2, 4-dithiazolidines (Hydrochloride)was synthesized by the interaction of 1-o-tolyl-3-aryl thiocarbamides with N-phenyl-S-chloro-isothiocarbamoyl chloride. Initially 1-o-tolyl-3-aryl thiocarbamides were prepared by the interaction of o-tolylisothiocyanate with different aryl amine in benzene medium. The structures of newly synthesized 1, 2, 4-dithiazolidines (Hydrochloride)have been established on the basis of chemical transformation, elemental analysis, and IR, 1H NMR, and Mass spectral studies. The title compounds have been assayed for their biological activity against gram-positive as well as gram-negative microorganisms namely Escherichia coli, Staphylococcus aureus, Penicillum notatumand Aspergillus niger. The title compounds showed most significant activity against the microbial strains used.

o-tolylisothiocyanate, aryl amine,thiocarbamides, isothiocarbamoyl chloride, 1, 2, 4-dithiazolidines (Hydrochloride), Antimicrobial activity.

"SYNTHESIS AND POTENTIAL ANTIMICROBIAL ACTIVITY OF SOME BIOLOGICALLY ACTIVE 4-ARYL-3, 5-DI-(O-TOLYLIMINO)-1, 2, 4-DITHIAZOLIDINES (HYDROCHLORIDE) ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.34-37, February-2020, Available :http://www.jetir.org/papers/JETIRDI06008.pdf

"SYNTHESIS AND POTENTIAL ANTIMICROBIAL ACTIVITY OF SOME BIOLOGICALLY ACTIVE 4-ARYL-3, 5-DI-(O-TOLYLIMINO)-1, 2, 4-DITHIAZOLIDINES (HYDROCHLORIDE) ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp34-37, February-2020, Available at : http://www.jetir.org/papers/JETIRDI06008.pdf