• Atish K. Maldhure
• Vijay H. Masand
• Nilima A. Kalambe
• Mahendrasingh J. Pawar
• Anil R. Somwanshi

Unsymmetrical Schiff Base transition metal (Mn2+, Co2+, Ni2+, Cu2+, Cr2+ and Fe2+) complexes with tetradentate unsymmetrical Schiff base ligand N-(5-bromo-2-hydroxyacetophenone)-N’-(2-hydroxyacetophenone)-2,6-diaminopyridinehas been synthesized by a simple method using DMF as a solvent and alcoholic ammonia to maintained the pH 7.5 -8.00. This ligand has been prepared by condensation reaction between 5-bromo-2-hydroxyacetophenone and o-hydroxyacetophenone with 2,6-diaminopyridine. The ligand and the prepared complexes have shown good to better antimicrobial activity against bacteria Staphalococcusaureus, Bacillus Subtilis, Salmonella typhimurium and Escherichia coli and fungi Aspergillusoryzae and Fusarium species. Furthermore, quantum mechanical and pharmacophore analyses of transition metal complexes and ligand reveals that on coordinating with metal, the pharmacophore pattern as well as the electron density distribution of a metal ligand changes significantly. This could be used for achieving specific type of pharmacophore pattern for deriving novel compounds with desired pharmacophore with targeted activity profile.

Unsymmetrical Schiff Base, Antimicrobial Activity, Pharmacophore analysis.

"Quantum mechanical and pharmacophore analyses of transition metal complexes of N-(5-bromo-2-hydroxyacetophenone)-N’-(2-hydroxyacetophenone)-2,6-diaminopyridine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.295-297, February-2020, Available :http://www.jetir.org/papers/JETIRDI06057.pdf

"Quantum mechanical and pharmacophore analyses of transition metal complexes of N-(5-bromo-2-hydroxyacetophenone)-N’-(2-hydroxyacetophenone)-2,6-diaminopyridine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp295-297, February-2020, Available at : http://www.jetir.org/papers/JETIRDI06057.pdf