• Pradip P. Deohate
• Kalpana A. Palaspagar

The (4,6-dimethyl-pyrimidin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl-pyrazol-3-yl)-amines have been prepared by cyclocondensation of N-(4,6-dimethyl-pyrimidin-2-yl)-3-oxo butyramide with substituted acid hydrazides under microwave. Synthesis of required 3-oxo butyramide was carried out by microwave irradiative condensation of 2-amino-4,6-dimethyl pyrimidine with ethyl acetoacetate. On acylation, the pyrimidine linked pyrazol-3-yl amines gave mono/di-acetyl derivatives. Structures of synthesized compounds were determined by IR, 1H-NMR, mass spectroscopic studies and elemental analysis as well as chemical transformation. So as to establish the relation between structure and biological activity, synthesized compounds have been evaluated against Pseudococcidae insects for their insecticidal activity and also against some selected microorganisms for antibacterial potential.

Pyrimidine, pyrazole, microwave, insecticidal, antimicrobial.

"SYNTHESIS OF PYRIMIDINE LINKED PYRAZOLE HETEROCYCLICS BY MICROWAVE IRRADIATIVE CYCLOCONDENSATION AND EVALUATION OF THEIR INSECTICIDAL AND ANTIBACTERIAL POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.476-479, February-2020, Available :http://www.jetir.org/papers/JETIRDI06092.pdf

"SYNTHESIS OF PYRIMIDINE LINKED PYRAZOLE HETEROCYCLICS BY MICROWAVE IRRADIATIVE CYCLOCONDENSATION AND EVALUATION OF THEIR INSECTICIDAL AND ANTIBACTERIAL POTENTIAL", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp476-479, February-2020, Available at : http://www.jetir.org/papers/JETIRDI06092.pdf