• Gauri P. Deshpande
• Dr. P.R. Solanki

Microwave radiation facilitated synthesis of di(substitutedphenyl)-pyrimid-5-one (Ia-Ij) by condensation of substituted amide(0.01M), aromatic aldehyde (0.015M)and amino acid(0.01M) in presence of metal salt as a catalyst. The reaction mixture was irradiated under scientific microwave oven for 1-2 minutes. The synthesized compounds were characterized by elemental analysis and IR, NMR, CMR, UV and Mass spectrum. Melting point are uncorrected and carried out on Thieles apparatus.The synthesized compound was screened for antimicrobial activities against Proteus vulgaris, Staphylococcus aureus, Escherichia coli and Salmonella typhi. The compounds showed good to moderate activity against the pathogens.

Condensation, Pyrimidine, microwave irradiation, Antimicrobial activities.

"Biological Evaluation of Some 6-dihydro-2, 4- di(substitutedphenyl)-pyrimid-5-one derivetives ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.480-482, February-2020, Available :http://www.jetir.org/papers/JETIRDI06093.pdf

"Biological Evaluation of Some 6-dihydro-2, 4- di(substitutedphenyl)-pyrimid-5-one derivetives ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp480-482, February-2020, Available at : http://www.jetir.org/papers/JETIRDI06093.pdf