• Nancy Bhura
• Jeena Gupta

Diabetes is the most common disease observed today, with the frequency of one person in almost every Indian house. India is the diabetic capital of the world, yet we do not have proper treatment strategies which can regulate this epidemic, and the number of infected individuals is increasing enormously. With the invent of technology and computational biology we can reduce time, effort and money to design and develop potential drug molecules. The altered epigenetic modifications (DNA and histone post-translational modifications which are heritable and regulate gene expression without changing the underlying DNA structure) are known to play an important role in the pathogenesis of diabetes. Methyl cinnamate and Vicenin 2 are the phytochemical commonly found in Ocimum genus, which also contains Holy Tulsi. Using Autodock Vina we have docked histone deacetylase (HDAC) and histone acetyl transferase (HAT) against these two phytochemicals to answer whether they can be considered as anti-diabetic targets or not. Our results show potential binding of methyl cinnamate with HDAC and vicenin 2 with HAT with lower binding energies highlighting them as potential epigenetic modulators and thus can be further evaluated for their protective effects against diabetes.

Phytomolecules methyl cinnamate and vicenin2 possess potential to modify epigenetic targets of diabetes: an in silico study

"Phytomolecules methyl cinnamate and vicenin2 possess potential to modify epigenetic targets of diabetes: an in silico study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 10, page no.201-206, October 2018, Available :http://www.jetir.org/papers/JETIRDQ06027.pdf

"Phytomolecules methyl cinnamate and vicenin2 possess potential to modify epigenetic targets of diabetes: an in silico study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 10, page no. pp201-206, October 2018, Available at : http://www.jetir.org/papers/JETIRDQ06027.pdf