• Satinder Kaur
• Kanwalpuneet Kaur
• Kamaldeep Kaur
• Navneet Khurana
• Shobit Bansal

Parkinson's disease is a neurodegenerative motor disorder characterized by three cardinal symptoms i.e. tremors, bradykinesia and rigidity of muscles. The pathogenesis of PD has remained unknown largely. It is a multifactorial disease which involves neuroinflammation, oxidative stress, environmental risk factor, mitochondrial dysfunction and protein aggregation as the possible causative factors. The pathological hallmarks of the disease is the dopaminergic neurodegeneration in the SNc and the presence of Lewy bodies, the cytoplasmic proteins aggregates in the DA cells. Of the multiple factors thought to be involved in the pathogenesis of PD, most attention has been given to oxidative stress in PD due to the potential that dopamine is metabolized oxidatively to ROS and H2O2. Deficiency of glutathione, increased iron and increased turnover of DA in the SNc give rise to oxidative stress and the resultant cell death. Neuroinflammation also has an important role in the PD pathogenesis. The microglial cells of CNS get activated in response to immunological injury, and give rise to production of various of substances of proinflammation and neurotoxic factors production of various of substances of proinflammation and neurotoxic factors. The agents for providing a good neuroprotection in PD could be those that inhibit the pathogenic factors, such as antioxidants, anti-inflammatory drugs.

Parkinson’s disease, Oxidative stress, Neuroinflammation.

"Oxidative Stress and Parkinson’s Disease: An Update", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.70-86, December 2018, Available :http://www.jetir.org/papers/JETIRDT06008.pdf

"Oxidative Stress and Parkinson’s Disease: An Update", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp70-86, December 2018, Available at : http://www.jetir.org/papers/JETIRDT06008.pdf