• Shelly Manhas
• Vandna Kalsi
• Barinderjit Kaur
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Ischemic preconditioning (IPC) represents a powerful endogenous protective mechanism against ischemia and reperfusion (I-R) induced myocardial injury. The major mechanism of ischemia and reperfusion- induced injury is oxidative stress. Several reports have demonstrated the protective effects of antioxidants as these agents known to be prevent myocardial damage by interacting with reactive oxygen species. Acacia auriculiformis is an antioxidant plant rich in glucuronic acid, methylglucuronic acid, galactose, rhamnose, arabinose, tannins as well as triterpenoid saponins. Therefore, the present study is designed to investigate the effect of Acacia auriculiformis ethanolic extract (100 mg/kg and 200 mg/kg) on myocardial I-R injury and IPC. The magnitude of I-R injury assessed in terms of myocardial infarct size, lactate dehydrogenase and creatine kinase. Acacia auriculiformis (100mg/kg and 200mg/kg) ethanolic extract has been found to provide cardioprotection by significantly reducing I-R injury assessed in terms of infarct size, LDH and CK concentrations. However, Acacia auriculiformis (100 mg/kg and 200 mg/kg) did not modulated the protective effect offered by IPC on heart.

: Acacia auriculiformis, Ischemic preconditioning, Ischemia reperfusion injury

"Cardioprotective effect of ethanol extract of Acacia auriculiformis in ischemic preconditioning", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.102-111, December 2018, Available :http://www.jetir.org/papers/JETIRDT06012.pdf

"Cardioprotective effect of ethanol extract of Acacia auriculiformis in ischemic preconditioning", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp102-111, December 2018, Available at : http://www.jetir.org/papers/JETIRDT06012.pdf