• PB Vandana1
• Mangesh Pradeep Kulkarni1
• Tusura Kanta Behera1
• Pardeep Kumar1
• Gurvinder Singh1

A considerable fraction of orally administered drug undergoes extensive first pass metabolism which poses a major challenge of bioavailability with certain drugs.The solution to this problem seems to exist with delivery of drug through buccal route. Owing to highly vasculararea and relatively higher permeability,the buccal mucosa offers a smart option for local as well as systemic delivery of various drugs. In addition, it may prolong the contact time of drug with affected site.This review attemptsto provide a brief idea about the buccal drug delivery including structural features of oral cavity, mechanism of buccal drug absorption, concept of bio adhesion, pharmaceutical considerations for dosage forms, methods of preparation and evaluation of buccal delivery systems along with some marketed products and patents granted thereon.

Buccal drug delivery, Bio adhesion, Oral mucosa, First pass metabolism

"BUCCAL DRUG DELIVERY SYSTEMS: A SMARTWAY TO DELIVER DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.256-269, December 2018, Available :http://www.jetir.org/papers/JETIRDT06031.pdf

"BUCCAL DRUG DELIVERY SYSTEMS: A SMARTWAY TO DELIVER DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp256-269, December 2018, Available at : http://www.jetir.org/papers/JETIRDT06031.pdf