• Diksha Gulati
• Sakshi Sharma
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Nano carrier as drug delivery system are rapidly spreading due to their more specificity towards particular receptor and show there action at specific site. Due to this property they are use specifically in cancer treatment. Nano particles are used in novel drug delivery system so as to reduce toxicity but nano carrier themselves becoming the reason for the toxicity.[1] Recent development in medicine has bring advancement in diagnose and treatment of disease but it also causes many hazards due to there toxicity. Nano particles have large surface area which binds to the surface of targeted receptor or cell, absorb at the surface and carry many drug particle or proteins. However, many challenges may overcome if the application of nano particles is improved and pathophysiology of disease is properly studied.[1] Nano particles may be synthetic or natural based upon their property the toxicity and action differs. So, for this the evaluations of nano particles are needed to be done. They may show different effects from previous effects. The main effect is shown on the brain as mentioned in various papers and articles.[1] Challenges with administration of dosage form The main routes for administration of any drug dosage form are Intravenous, Intramuscular, Intranasal, Intradermal and oral dosage form. Other routes are also there for the administration such as ocular delivery which have been developed for localized and site-specific delivery of drug.[2] The nano particles are advanced technology in medicine and dosage form not always these routes mention above show there effect so nano particles emerged in the pharmaceutical areas. Drug like proteins or nucleic acid require more innovative carrier to target the active pharmaceutical ingredient and administer drug to required site. [3] Absorption mechanism and nature of the drug determine the delivery system for better bioavailability and better efficacy.[2]

oral administration ,gastrointestinal environment

" Nano carrier as drug delivery system and their associated complications ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.304-308, December 2018, Available :http://www.jetir.org/papers/JETIRDT06034.pdf

" Nano carrier as drug delivery system and their associated complications ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp304-308, December 2018, Available at : http://www.jetir.org/papers/JETIRDT06034.pdf