• Geetanshu Goyal
• Daljeet Singh Dhanjal
• Chirag Chopra
• Reena Singh

Dietary restriction (DR) is one of the effective ways to regulate the ageing as well as to improve the lifespan of diverse model organisms, which could range from unicellular yeast to primates. As in dietary restriction, there is a restriction of 20-35% in food intake as compared to regular intake. DR requires a strict intervention which has both benefits and adverse effects. However, a certain type of chronic, intermittent, or periodic caloric restrictions has shown significant result which aids in improving the lifespan and minimise the detrimental effects. Enhanced regular caloric dietary restriction approach could be planed as a safe intervention for the benefit of the individuals. Here, in this review, we will discuss the effect of caloric restriction on IGF1 and mTOR, ageing and age-related disease. In this review, the effects of CR on the brain, ageing, age-related disorders and IGF1 are covered. We will also discuss the effect of caloric restriction on IGF1 and mTOR, ageing and age-related disease. Further, it will discuss the salient aspects of intermittent fasting and starvation.

Aging, Caloric Restriction, Dietary Restriction, Starvation, Life span.

"MOLECULAR ANALYSIS OF DIETARY RESTRICTION AND STARVING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.483-489, December 2018, Available :http://www.jetir.org/papers/JETIRDT06063.pdf

"MOLECULAR ANALYSIS OF DIETARY RESTRICTION AND STARVING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp483-489, December 2018, Available at : http://www.jetir.org/papers/JETIRDT06063.pdf