• Harpreet Singh
• Tapan Kumar

BACKGROUND: Any foreign agents like drugs upon administration to a living system has to pass through the various bio-fluids, interact with effective components in the body-fluid and thereby face multiple biological barriers to reach the target sites. Therefore, the assessment of sulpha drugs, worked as antibiotics, for their potential interactions with effective and edible electrolytes and vitamins present in body-fluid is important. RESULTS: Interactions studies of sulpha drugs like sulphanilamide and sulphanilic acid, important drug compounds from the class of sulphonamides, have been carried out with PEG and electrolytes present in the bio-fluid, using UV-visible and fluorescence spectroscopy. The absorption and emission maximum obtained from both the drugs diminishes with the addition of PEG, suggesting the hydrophilic type of interactions between the drug compounds and PEG. When this drug-PEG complex is subjected to aqueous solutions of electrolytes; chloride and sulphates of sodium, potassium, magnesium and calcium, strong quenching in absorption maximum have been observed, suggesting the existence of the active hydrophilic/electrostatic type of interactions between the drugs-PEG complexes. Furthermore, those sulpha drugs showed similar binding patterns with that of vitamins. CONCLUSION: Our result suggests the presence of strong hydrophilic interactions in the drug-PEG complexes due to the presence of many hydrophilic sites in the structure of drug molecules and PEG in aqueous solutions. Quantifying these binding interactions is necessary for understanding any alteration in the effectiveness of a new sulpha drug towards its usage as antibacterial medicine as well as will be helpful further to assess the possibilities of a new sulpha drug. Highlights • Interactions studies focused on two sulphonamides drugs with PEG in solution • PEGylated drugs were tested with various electrolytes commonly found in biofluide • Both absorption and emission spectrophotometric measurements provide binding events • The binding results have been interpreted in terms of hydrophilic and hydrophobic interactions • PEGylation enhances drugs for its affinity towards the bio-compatible electrolytes List of Abbreviation: SM: sulphanilamide, SA: sulphanilic acid, PEG: polyethylene glycol, CNS: the central nervous system; LAA: Vit C=L-Ascorbic Acid; NA: Vit B3=Nicotinic Acid;

Sulpha Drugs, Electrolytes, vitamins

"Novel insights into the molecular interactions of commercial sulpha drugs with effective edible electrolytes and vitamins present in body-fluid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.885-899, December 2018, Available :http://www.jetir.org/papers/JETIRDZ06115.pdf

"Novel insights into the molecular interactions of commercial sulpha drugs with effective edible electrolytes and vitamins present in body-fluid", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp885-899, December 2018, Available at : http://www.jetir.org/papers/JETIRDZ06115.pdf