• Kapil Rajput

The transdermal patch is a polymeric-based patch that contains a distributed bioactive ingredient that delivers therapeutic agents across the human skin surface at a constant rate. In this analysis, the dual layer PVA patch was prepared using a combination of freezing- thawing (F-T) and electrospinning techniques to research the effect of F-T cycles on the manufactured patch's morphological structure and swelling ratio. Using Scanning Electron Microscopy (SEM) and immersion of dual layer PVA patch for 24 hours in distilled water, the effect of F-T cycles on swelling potential as well as the morphological analysis of the patch was employed and characterized. The connection between PVA cryogel and PVA electrospun nanofiber membrane has been shown by the morphological structure of dual layer PVA sheet. The results revealed that the dual layer PVA patch had been successfully manufactured as the nanofiber membrane under layer PVA electrospun does not dissolve completely in the F-T phase. In addition, it is shown in this study that the increase in F-T cycles has decreased the swelling potential of the dual layer PVA patch. It also found that the presence of PVA electrospun nanofiber, due to the high surface ratio of the electrospun nanofiber membrane, has also affected the swelling capability of the dual layer PVA patch. The highest percentage of swelling ratio for dual layer PVA with 3 cycles (2L-3C) was found to be close to 66 percent, while for dual layer PVA with 5 cycles (2L-5C) the percentage was found to be slightly lower (33 per cent). The enhancement of dual layer PVA patch can be used to test drug release and may also be a successful option for delivery of transdermal drugs.

Poly-vinyl Alcohol (PVA), Electrospun Nanofibers, Freezing-thawing, Swelling Ratio.

"Effect of Freezing-Thawing Cycles on Morphological and Swelling Potential", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.175-180, January 2019, Available :http://www.jetir.org/papers/JETIREO06040.pdf

"Effect of Freezing-Thawing Cycles on Morphological and Swelling Potential", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp175-180, January 2019, Available at : http://www.jetir.org/papers/JETIREO06040.pdf