• Krishan Raj Singh

“T-cell Acute Lymphoblastic Leukaemia” (T-ALL) has emerged as one the most infamous of all the cancers currently afflicting mankind. However, its treatment is marred by the high cost and many side-effects which in turn have spurred the need for alternative anti-cancer agents. Nowadays many anti-cancer drugs have been isolated from plants. In this paper, Methanolic fraction of the leaves of Tomato (Solanum lycopersicum L) has been evaluated for its anti-T-ALL activity. The methanolic fraction of the Tomato leaves was treated on a T-ALL; MOLT-3 and on a normal human embryonic kidney (nHEK) and its growth inhibitory activity was noted. The IC50 value after 24 h came at 40.48 µg/ml on MOLT-3 cells however; no activity was seen on nHEK cell lines. Based on these findings, it can be safely assumed that the methanolic fraction of Tomato leaves can be utilized as an anti- T-ALL agent. The discovered carotenoids and phenolic acids, as well as a number of minor chemicals exerting their synergistic impact, might be attributed to these biological characteristics.

Apoptosis, Cells, IC50 value, Methanolic fraction, MOLT-3, T-Acute Myelogenous Leukaemia (T-ALL), Tomato leaves.

"Anti-T-Cell Acute Lymphoblastic Leukaemia Effect Using Methanolic Fraction of the Leaves of Tomato (Solanum Lycopersicum L)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 10, page no.673-678, October-2018, Available :http://www.jetir.org/papers/JETIRFH06113.pdf

"Anti-T-Cell Acute Lymphoblastic Leukaemia Effect Using Methanolic Fraction of the Leaves of Tomato (Solanum Lycopersicum L)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 10, page no. pp673-678, October-2018, Available at : http://www.jetir.org/papers/JETIRFH06113.pdf