• Shivangi
• Krishan Raj Singh

Leukaemia has emerged as one of the most lethal of the cancers in the modern era. Out of all Leukaemia, Acute Myelogenous Leukaemia (AML) is the most notorious. The treatment regime being expensive & toxic has led to a world-wide hunt for alternate sources of anti-AML agents. In the various traditional systems of medicines, the Indian rose (Rosa indica) has been recorded as having various health benefits. In this paper, the Ethanolic extract of Rose was investigated for its anti-AML activity. The investigators treated both the AML cell line, HL-60 & the Normal Human Embryonic Kidney cell lines (NHEK) with varying doses of the Rosa indica’s Ethanolic extract for 24 h. Based on the current observations, the Rosa indica’s Ethanolic extract induced growth inhibition having IC50 44.44 µg/ml. Moreover, the ethanolic extract showed negligible activity against normal cell lines. Based on these findings, it can be safely assumed that the ethanolic fraction of the Indian Rose can be utilized as an anti-AML agent.

Apoptosis, Acute Myelogenous Leukaemia (AML), Cells, Ethanolic Fraction, IC50 Value, HL-60, Reactive Oxygen Species (ROS), Rosa Indica.

"A Review Paper on Medicinal Plants with Anti-Leukemic Effects", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 10, page no.679-685, October-2018, Available :http://www.jetir.org/papers/JETIRFH06114.pdf

"A Review Paper on Medicinal Plants with Anti-Leukemic Effects", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 10, page no. pp679-685, October-2018, Available at : http://www.jetir.org/papers/JETIRFH06114.pdf