• Mallikarjun Kote

Adipic hydrazides are very important and wide applications of nitrogen containing heterocyclic compounds, possessing broad spectrum of biological and pharmacological activities such as hypotensive1, anticancer, anti-HIV, anti-inflammatory2, analgesic, antiviral, antitubercular, antimicrobial, anti-bacterial, antipyretic, antimitotic, anticonvaulsant3, anticoagulant, anti-fibrillatory, cardiac stimulant and diuretic.4 The quinoline have been tested successfully against cancer and HIV virus.5 Their synthetic analogues possess antimalarial, hypolipidemic and antiproliferative activities6 . The coordination chemistry of adipic hydrazide ligands has received much attention because of its biological implications. 2-amino-5-iodo benzoic acid hydrazide derivatives exhibit very potent antifungal and antibacterial activities.7 These 2-amino-5-iodo benzoic acid derivatives are covered the area of biological interest of this compounds have extended recently to various microbial activities such as analgesic, diuretic, anti-inflammatory, anthelmintic, antipruritic activities8 and this class of compound showed in vitro selective anti-helicobacter pylori activity. In view of these factors the metal complexes of the ligand L4= (N'1E, N’6E)-N1',N6’-bis ( ( 2 - hydroxyquinolin-3-yl)methylene)adipohydrazide , L5 = (N'1E, N’6E)-N'1, N’6 – bis ( ( 6-bromo-2-hydroxyquinolin-3-yl)methylene) adipohydrazide, L6= (N1 E,N6E)-N1' N6’-bis ((2-hydroxy 6-methylquinolin-3-yl)methylene)adipohydrazide.

DNA CLEAVAGE AND BIOLOGICAL STUDIES OF LIGANDS AND ITS METAL (II) COMPLESES

"DNA CLEAVAGE AND BIOLOGICAL STUDIES OF LIGANDS AND ITS METAL (II) COMPLESES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 12, page no.202-210, December-2021, Available :http://www.jetir.org/papers/JETIRFI06032.pdf

"DNA CLEAVAGE AND BIOLOGICAL STUDIES OF LIGANDS AND ITS METAL (II) COMPLESES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 12, page no. pp202-210, December-2021, Available at : http://www.jetir.org/papers/JETIRFI06032.pdf